diff --git a/.gitignore b/.gitignore
index e3f7150..c7419b5 100644
--- a/.gitignore
+++ b/.gitignore
@@ -7,6 +7,7 @@ __pycache__/
 chembl_*.txt
 
 # Files generated by scimesh workloads
+results/
 *_similarities.csv
 test_results.csv
 test_structures/
diff --git a/scimesh/cli.py b/scimesh/cli.py
index c144de6..683cf3c 100644
--- a/scimesh/cli.py
+++ b/scimesh/cli.py
@@ -14,6 +14,7 @@ def build_parser() -> argparse.ArgumentParser:
     parser = argparse.ArgumentParser(
         prog="scimesh",
         description="Run local scientific workloads on molecular datasets.",
+        epilog="Run 'scimesh help' for a quick start and copy-paste examples.",
     )
     subparsers = parser.add_subparsers(dest="workload", required=True)
     registry = WorkloadRegistry()
diff --git a/scimesh/workloads/__init__.py b/scimesh/workloads/__init__.py
index e74bfc1..e5cc2f1 100644
--- a/scimesh/workloads/__init__.py
+++ b/scimesh/workloads/__init__.py
@@ -3,11 +3,13 @@
 from __future__ import annotations
 
 from scimesh.core.registry import WorkloadRegistry
+from scimesh.workloads.help import HelpWorkload
 from scimesh.workloads.similarity_graph import SimilarityGraphWorkload
 from scimesh.workloads.similarity_search import SimilaritySearchWorkload
 
 
 def register_workloads(registry: WorkloadRegistry) -> None:
     """Register built-in workloads in one place, outside the main CLI."""
+    registry.register(HelpWorkload())
     registry.register(SimilaritySearchWorkload())
     registry.register(SimilarityGraphWorkload())
diff --git a/scimesh/workloads/help.py b/scimesh/workloads/help.py
new file mode 100644
index 0000000..a220195
--- /dev/null
+++ b/scimesh/workloads/help.py
@@ -0,0 +1,65 @@
+"""Quick-start help workload."""
+
+from __future__ import annotations
+
+import argparse
+from textwrap import dedent
+
+
+HELP_TEXT = dedent(
+    """\
+    SciMesh quick start
+    ===================
+
+    SciMesh runs molecular similarity workloads locally. Input must be a ChEMBL TSV
+    with chembl_id and canonical_smiles columns.
+
+    1. Activate the project environment and create a directory for outputs:
+
+       source .venv/bin/activate
+       mkdir -p results
+
+    2. Find molecules similar to gefitinib (CHEMBL939):
+
+       scimesh similarity-search chembl_37_chemreps.txt \\
+         --query-id CHEMBL939 \\
+         --top-k 20 \\
+         --max-rows 10000 \\
+         --output results/gefitinib_top20.csv
+
+    3. Search by a SMILES query instead of a ChEMBL ID:
+
+       scimesh similarity-search chembl_37_chemreps.txt \\
+         --query-smiles 'CCO' \\
+         --top-k 20 \\
+         --output results/smiles_search.csv
+
+    4. Build a small exact similarity graph:
+
+       scimesh similarity-graph chembl_37_chemreps.txt \\
+         --max-rows 1000 \\
+         --threshold 0.7 \\
+         --block-size 250 \\
+         --output results/similarity_graph.csv
+
+    Use --max-rows for quick local tests; omit it to process the full dataset.
+    For all options, run:
+
+       scimesh similarity-search --help
+       scimesh similarity-graph --help
+    """
+)
+
+
+class HelpWorkload:
+    """Expose practical examples without adding special logic to the main CLI."""
+
+    name = "help"
+    help = "Show a quick start and runnable examples."
+
+    def configure_parser(self, parser: argparse.ArgumentParser) -> None:
+        parser.description = "Show SciMesh setup and usage examples."
+
+    def run(self, args: argparse.Namespace) -> int:
+        print(HELP_TEXT)
+        return 0
diff --git a/tests/test_cli_help.py b/tests/test_cli_help.py
new file mode 100644
index 0000000..ee193d2
--- /dev/null
+++ b/tests/test_cli_help.py
@@ -0,0 +1,11 @@
+from __future__ import annotations
+
+from scimesh.cli import main
+
+
+def test_help_command_prints_runnable_examples(capsys: object) -> None:
+    assert main(["help"]) == 0
+    output = capsys.readouterr().out
+    assert "scimesh similarity-search" in output
+    assert "scimesh similarity-graph" in output
+    assert "mkdir -p results" in output